Combinatorial effects of coral addition and plasma treatment on the properties of chitosan/polyethylene oxide nanofibers intended for bone tissue engineering
نویسندگان
چکیده
Given the complex calcified nature of fibrous bone tissue, a combinatorial approach merging specific topographical/biochemical cues was adopted to design tissue-engineered scaffolds. Coral having Ca-enriched structure added electrospun chitosan (CS)/polyethylene oxide (PEO) nanofibers that were subjected plasma surface modifications using medium pressure Ar, air or N2 dielectric barrier discharge. Plasma incorporated oxygen- and nitrogen-containing functionalities onto thus enhancing their wettability. treatment enhanced performance osteoblasts interplay between coral shown boost initial cell adhesion. The fibers capacity trigger calcium phosphate growth predicted via immersion in simulated body fluid. Globular carbonate apatite nanocrystals deposited on plasma-treated CS/PEO NFs while thicker layers flake-like covering Coral/CS/PEO without blocking interfibrous pores. Overall, exclusive multifaceted are believed revolutionize tissue engineering field.
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ژورنال
عنوان ژورنال: Carbohydrate Polymers
سال: 2021
ISSN: ['1879-1344', '0144-8617']
DOI: https://doi.org/10.1016/j.carbpol.2020.117211